PRP and PRF for Periocular Rejuvenation

The delicate skin around the eyes is often the first area to show fatigue, discoloration, and the fine textural changes of aging. Increasingly, patients are searching for natural, minimally invasive ways to refresh this region without surgery or synthetic materials. Platelet-rich plasma (PRP) and its newer relative, platelet-rich fibrin (PRF), have emerged as popular options because they harness healing factors from your own blood. When performed thoughtfully — particularly by a physician who understands the intricate anatomy of the eyelids and orbit — these treatments can improve skin quality, soften under-eye dark circles, and enhance the results of other rejuvenation procedures.

This page explains what PRP and PRF actually are, how their growth factors work biologically, where they help most around the eyes, and — importantly — where the evidence is strong and where it remains preliminary. As oculoplastic surgeons, we believe patients deserve an honest, anatomically informed discussion rather than the marketing enthusiasm often found in non-medical settings.

PRP vs. PRF: What’s the Difference?

Both PRP and PRF begin the same way: a small sample of your blood is drawn and placed in a centrifuge, which separates the components by density. The goal is to concentrate platelets — the tiny cell fragments that release healing growth factors — and re-inject or apply them to tissue that needs regeneration. The differences lie in how the blood is processed.

PRP (platelet-rich plasma) is the first-generation product. Blood is drawn into a tube containing an anticoagulant (to prevent clotting), then spun at a relatively high speed. This produces a liquid plasma rich in platelets that can be injected or applied topically. Because it stays liquid, PRP delivers a rapid burst of growth factors.

PRF (platelet-rich fibrin) is considered a second-generation, more “natural” product. It is spun at a slower speed and, critically, uses no anticoagulant. Without anticoagulant, the blood begins to form a soft fibrin clot as it spins. This fibrin scaffold traps platelets and white blood cells, and it releases growth factors gradually over about a week rather than all at once. PRF is typically richer in leukocytes and fibrin, though relative platelet content varies by preparation protocol.

How Growth Factors Work

The therapeutic power of PRP and PRF lies in the growth factors stored within platelet granules. When platelets are concentrated and activated, they release a cascade of signaling proteins that orchestrate the body’s natural repair processes. The key players relevant to skin rejuvenation include:

• PDGF (platelet-derived growth factor) — stimulates cell proliferation, recruits fibroblasts, and promotes new blood-vessel formation and tissue repair.
• TGF-β (transforming growth factor beta) — a central driver of collagen and extracellular matrix production, helping firm and thicken thin periocular skin.
• VEGF (vascular endothelial growth factor) — promotes healthy microcirculation, which may improve tissue oxygenation and the appearance of the skin.
• EGF (epidermal growth factor) — supports keratinocyte turnover and epidermal renewal, improving smoothness and tone.

Together, these factors nudge the skin toward a regenerative state: fibroblasts lay down new collagen and elastin, dermal thickness gradually increases, and microvascular quality may improve. Over weeks to months, patients often notice firmer, better-hydrated, more resilient skin. Some studies also suggest an effect on melanin regulation — potentially helping the pigmentary component of dark circles — though this mechanism is less well established than the collagen-building effects.

Because the material comes entirely from your own body, the risk of allergic reaction or rejection is very low, which is one of PRP/PRF’s appealing features (though additives used in processing and injection-related complications can still occur).

Periocular Applications

The under-eye region is uniquely suited to regenerative approaches because the skin here is the thinnest on the body and shows early signs of thinning, discoloration, and crepiness.

Under-eye dark circles

Dark circles have several causes, and PRP/PRF addresses some better than others. The vascular component — the bluish-purple tint from visible vessels and stagnant blood beneath thin skin — may respond as growth factors thicken the overlying dermis and improve microcirculation, making the underlying color less apparent. A hollow (structural) component from volume loss responds better to fillers or fat grafting. Purely pigmentary dark circles may improve modestly but often need adjunctive treatment. A careful evaluation determines which mechanism dominates.

Skin quality and texture

For patients with fine lines, crepey texture, or dull, thin skin who are not ready for surgery or laser resurfacing, PRP/PRF offers a gentle route to gradual improvement in firmness and radiance.

Augmenting other treatments

PRP and PRF are frequently used to enhance other procedures rather than as standalone therapies — boosting healing and collagen response when combined with RF microneedling or fat grafting.

Treatment Protocol

A typical periocular PRP/PRF session is straightforward and completed in the office in about 45–60 minutes:

1. Consultation and mapping. Dr. Sakol evaluates the cause of your concerns — distinguishing vascular, structural, and pigmentary contributions — and marks treatment zones.
2. Blood draw. A small sample (typically 10–20 mL, similar to a routine lab draw) is taken from your arm.
3. Centrifugation. The tubes are spun for several minutes. PRP uses a faster spin with anticoagulant; PRF uses a slower spin without anticoagulant to form the fibrin matrix.
4. Preparation. The platelet-rich layer is drawn off into a syringe. Topical numbing cream and/or fine local anesthesia is applied for comfort.
5. Application. The material is either injected in small aliquots into the dermis and superficial tissue (using blunt or fine-gauge technique) or applied topically in combination with microneedling, which creates channels for absorption.

Evidence and Limitations

We believe in transparency about what PRP and PRF can and cannot do. The scientific literature supporting regenerative treatments for periocular skin is growing but less robust than the evidence behind established surgical and laser procedures.

What the evidence supports reasonably well:

• Modest improvements in skin thickness, texture, and elasticity, consistent with a collagen-building mechanism.
• Improvement in some cases of vascular-type dark circles, likely from dermal thickening and improved microcirculation.
• An adjunctive benefit — faster healing and enhanced results — when combined with microneedling or resurfacing.

Where the evidence is weaker or inconsistent:

• Preparation methods vary widely between clinics, so results are not standardized and studies are hard to compare.
• Effects are typically subtle and gradual, not dramatic — patients expecting results comparable to surgery or fillers may be disappointed.
• Long-term durability data are limited, and repeat sessions are usually needed.

Number of Sessions

Because PRP and PRF stimulate a gradual biological response rather than adding volume directly, a series of treatments produces the best results. A typical periocular protocol involves:

Because the improvement accumulates, patience is essential. Most patients see the fullest benefit a few months after completing the initial series, when new collagen has matured.

Combination Treatments

PRP and PRF often deliver their greatest value as part of a layered treatment plan. Combining regenerative therapy with other modalities addresses multiple contributors to periocular aging simultaneously.

PRP/PRF + RF microneedling

This is one of the most popular pairings. RF microneedling creates controlled micro-injuries and delivers radiofrequency heat to stimulate collagen; applying PRP/PRF into the resulting channels supplies concentrated growth factors exactly where the healing response is activated. Many patients report improved texture and reduced downtime with the combination.

PRP/PRF + fat grafting

When PRP is mixed with harvested fat during facial fat grafting, the growth factors may improve graft survival and skin-quality outcomes over the treated area — combining structural volume with regenerative support.

PRP/PRF + laser resurfacing

Following laser resurfacing, topical PRP/PRF may accelerate epidermal recovery and reduce redness, smoothing the healing process.

Why an Oculoplastic Surgeon?

PRP and PRF are widely offered in medspas and non-medical settings, but the periocular region is not a place for casual treatment. The area is only millimeters from the eye itself and is densely populated with critical structures: the angular and supratrochlear vessels, the orbital septum, the lacrimal drainage system, and the levator mechanism that lifts the eyelid. An injection placed carelessly here can cause serious complications — from prolonged bruising to, in rare instances, intravascular injection causing tissue necrosis or vision loss.

Oculoplastic surgeons are ophthalmologists with additional ASOPRS fellowship training focused entirely on the eyelids, tear ducts, and orbit. This means we approach periocular PRP differently:

• Anatomical precision. We know the depth and location of periocular vessels and inject in safe planes to minimize vascular risk.
• Accurate diagnosis. We distinguish vascular, pigmentary, and structural causes of dark circles — and recognize when a hollow tear trough, eyelid laxity, or fat prolapse is the true problem, requiring a different treatment entirely.
• Honest expectation-setting. We recommend PRP only when it is likely to help, and we will tell you plainly when surgery, fillers, or other options would serve you better.
• Eye safety. Should any complication arise, we are trained and equipped to manage it and to protect your vision.

If you are considering PRP or PRF to refresh the skin around your eyes, soften dark circles, or enhance another rejuvenation procedure, the most important first step is an evaluation with a qualified specialist who can identify the true source of your concerns and design a safe, realistic plan. To connect with an ASOPRS fellowship-trained oculoplastic surgeon experienced in regenerative periocular treatments, Find a Doctor near you and schedule a personalized consultation.